孫光蕙

Kuang-Hui Sun

聯絡方式

〒 研究大樓2F R226

實驗室分機：02-2826-7000 轉65827 (Lab)  

孫老師信箱：khsun@nycu.edu.tw

學歷

國立陽明大學 微免所碩士

國立陽明大學 微免所博士

研究方向

Molecular pathogenesis of lupus

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease. One of the characteristics is the presence of autoantibodies against double-stranded-DNA (anti-dsDNA) in serum at high levels. In addition, bacterial infections are associated with higher morbidity and mortality in SLE. However,interaction between the risk factors in the pathogenesis of lupus remains to be determined. Furthermore, current therapies for SLE including steroids and immunosuppressive agents have more side effects. Therefore, we focus on the roles of infection (innate immunity) and anti-dsDNA in the pathogenesis of SLE. Moreover, these results may also provide molecular targets for the development of new drugs. The new therapeutic strategies may be alternatives for the classical steroid treatment for SLE.

 

Molecular tumorigenesis and novel immunotherapy of cancer

The tumor microenvironment consists of immune cells, mesenchymal-derived cells, fibroblasts, surrounding blood vessels, signaling molecules, and the extracellular matrix. It forms a complex regulatory network that fosters tumor growth by evading immune surveillance and destruction. Tumors also can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance. Therefore, the tumor microenvironment contributes to tumor initiation, tumor progression and responses to therapy. The clinical therapies of lung cancer, head neck cancer and renal cell carcinomas are based on combined chemotherapy or molecular targeting therapy. However, the overall survival rate has improved only marginally and the relapse rate is high. Defining the factors involved in the tumor microenvironment for disease progression and metastasis will provide molecular targets for the development of effective therapies. Therefore, we focus on the molecules of tumor microenvironmentin the cancer progression, including galectin family, proinflammatory cytokines, chemokines and receptors. In addition, we develop cancer immunotherapy.

研究著作

  1. Tzu-Chun Hung, Tien-Jen Liu, Wen-Yeh Hsieh, Bo-Nien Chen, Wen-Ko Su,Kuang-Hui Sun, Christian Guilleminault. A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults. Sleep and Breathing 2019; (SCI). (Impact factor: 2.03;Rank: 65.23%)通訊作者

  2. Huang CS, Tang SJ, Lee MH, Chang Wang CC, Sun GH, Sun KH. Galectin-3 promotes CXCR2 to augment the stem-like property of renal cell carcinoma. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2018; 22(12):5909-5918. (SCI). (Impact factor: 4.302;Rank: 18.42%)通訊作者

  3. Chi-Jui Liu, Chang-Youh Tsai, Ssu-Hsuan Chiang, Shye-Jye Tang, Nien-Jung Chen, Tak Wah Mak, Guang-Huan Sun, Kuang-Hui Sun. Triggering receptor expressed on myeloid cells-1 (TREM-1) deficiency augments BAFF production to promote lupus progression. JOURNAL OF AUTOIMMUNITY 2017; 78:92-100 (SCI). (Impact factor: 7.607;Rank: 9.35%)第一或通訊作者
  4. Kuang-Hui Sun, Guang-Huan Sun, Yi-Ching Wu, Bai-Jiun Ko, Hui-Tzu Hsu, Sheng-Tang Wu. TNF-a Augments CXCR2 and CXCR3 to Promote Progression of Renal Cell Carcinoma. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2016; 20(11):2020-2028 (SCI). (Impact factor: 4.302;Rank: 18.42%)第一或通訊作者
  5. Yi-Ching Wu, Shye-Jye Tang, Guang-Huan Sun, and Kuang-Hui Sun. CXCR7 mediates TGFβ1-promoted EMT and tumor initiating features in lung cancer. ONCOGENE 2016; 35(16):2123-32 (SCI). (Impact factor: 6.854;Rank: 8.48%)第一或通訊作者

  6. Tsou YC, Wang HH, Hsieh CC, Sun KH, Sun GH, Jhou RS, Lin TI, Lu SY, Liu HY, Tang SJ.. Down-regulation of BNIP3 by olomoucine, a CDK inhibitor, reduces LPS- and NO-induced cell death in BV2 microglial cells . NEUROSCIENCE LETTERS 2016; 628:186-93 (SCI). (Impact factor: 2.159;Rank: 71.84%)第四或以後作者

  7. Lee MY, Sun KH, Chiang CP, Huang CF, Sun GH, Tsou YC, Liu HY, Tang SJ.. Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90. EXPERIMENTAL BIOLOGY AND MEDICINE 2015; 240(4):240(4):498-507 (SCI). (Impact factor: 2.413;Rank: 56.77%)第二作者
  8. Ling-Yen Chung, Shye-Jye Tang, Yi-Ching Wu, Guang-Huan Sun, Huan-Yun Liu, and Kuang-Hui Sun. Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with b-catenin. Oncotarget 2015; 6(7):4936-52. (SCI). (Impact factor: 5.168;Rank: 20.05%)第一或通訊作者

  9. Lee TP, Huang JC, Liu CJ, Chen HJ, Chen YH, Tsai YT, Yang W, Sun KH.. Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgene mice. Experimental Biology and Medicine 2014; 239:715-23 (SCI). (Impact factor: 2.413;Rank: 56.77%)第一或通訊作者

  10. Huang CS, Tang SJ, Chung LY, Yu CP, Ho JY, Cha TL, Hsieh CC, Wang HH, Sun GH, Sun KH.. Galectin-1 Upregulates CXCR4 to Promote Tumor Progression and Poor Outcome in Kidney Cancer. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2014; 25:1486-95 (SCI). (Impact factor: 8.655;Rank: 3.29%)第一或通訊作者
  11. Cha TL, Chuang MJ, Tang SH, Wu ST, Sun KH, Chen TT, Sun GH, Chang SY, Yu CP, Ho JY, Liu SY, Huang SM, Yu DS.. Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth . MOLECULAR CARCINOGENESIS 2013; : (SCI). (Impact factor: 3.851;Rank: 28.16%)第四或以後作者
  12. Hsiao-Ying Chiu, Guang-Huan Sun, Shiow-Yi Chen, Hsiao-Hsien Wang, Ming-Yi Ho, Chia-Yi Chu, Wan-Lin Wu, Ren-Shiang Jhou, Yi-Lin Tsai, Rui-Ting Huang, Kuang-Hui Sun, Shye-Jye Tang*. Pre-existing Fas ligand (FasL) in cancer cells elicits tumor-specific protective immunity, but delayed induction of FasL expression after inoculation facilitates tumor formation. MOLECULAR CARCINOGENESIS 2013; 52:705-14 (SCI). (Impact factor: 3.851;Rank: 28.16%)第一或通訊作者
  13. Hsu, Hui-Ling; Huang, Hsin-Hsien; Liang, Chung-Chih; Lin, Hung-Chi; Liu, Wen-Tssann; Lin, Feng-Ping; Kau, Jyh-Hwa; Sun, Kuang-Hui. Suspension bead array of the single-stranded multiplex PCR amplicons for enhanced identification and quantification of multiple pathogens. ANALYTICAL CHEMISTRY 2013; 85(11):5562-8 (SCI). (Impact factor: 6.042;Rank: 4.32%)第一或通訊作者
  14. Chuang MJ, Wu ST, Tang SH, Lai XM, Lai HC, Hsu KH, Sun KH, Sun GH, Chang SY, Yu DS, Hsiao PW, Huang SM, Cha TL.. The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation . PLoS One 2013; 8(9):e73401 (SCI). (Impact factor: 2.766;Rank: 22.66%)第四或以後作者
  15. Ming-Yi Ho, Shye-Jye Tang, Mei-Jen Chuang, Tai-Lung Cha, Jing-Yao Li, Guang-Huan Sun, Kuang-Hui Sun. TNF-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a GSK3β-dependent mechanism. MOLECULAR CANCER RESEARCH 2012; 10:1109-19 (SCI). (Impact factor: 4.597;Rank: 25.34%)第一或通訊作者
  16. Hsiao-Ying Chiu, Kuang-Hui Sun, Shiow-Yi Chen, Hsiao-Hsien Wang, Ming-Yung Lee,Yu-Chi Tsou, Shyh-Chuan Jwo, Guang-Huan Sun, Shye-Jye Tang. Autocrine CCL2 promotes cell migration and invasion via PKC activation and tyrosine phosphorylation of paxillin in bladder cancer cells. CYTOKINE 2012; 59 :423–432 (SCI). (Impact factor: 3.514;Rank: 34.30%)第二作者
  17. Ling-Yen Chung, Shye-Jye Tang, Guang-Huan Sun, Teh-Ying Chou, Tien-Shun Yeh, Sung-Liang Yu and Kuang-Hui Sun. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK and cyclooxygenase-2. CLINICAL CANCER RESEARCH 2012; 18:4037-47 (SCI). (Impact factor: 10.199;Rank: 5.16%)第一或通訊作者
  18. Ho MY, Tang SJ, Sun KH, Yang W. Immunotherapy for lung cancers. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 2011; 2011(250860): (SCI). (Impact factor: 3.169;Rank: 28.22%)第一或通訊作者
  19. Hung KS, Chen SY, Liu HF, Tsai BR, Chen HW, Huang CY, Liao JL, Sun KH, Tang SJ.. C-terminal region of Candida rugosa lipases affects enzyme activity and interfacial activation . JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2011; 59(10):5396-401. (SCI). (Impact factor: 3.412;Rank: 2.63%)第四或以後作者
  20. Hung KS, Liu SM, Fang TY, Tzou WS, Lin FP, Sun KH, Tang SJ.. Characterization of a salt-tolerant xylanase from Thermoanaerobacterium saccharolyticum NTOU1 . BIOTECHNOLOGY LETTERS 2011; 33(7):1441-7. (SCI). (Impact factor: 1.846;Rank: 61.18%)第四或以後作者
  21. Sheng-Tang Wu, Guang-Huan Sun, Chih-Ying Hsu, Chang-Shuo Huang, Yu-Hsin Wu, Hsiao-Hsien Wang and Kuang-Hui Sun. TNF-alfa induces epithelial-mesenchymal transition of renal cell carcinoma cells via a NF-kB-independent mechanism. EXPERIMENTAL BIOLOGY AND MEDICINE 2011; 236 :1022–1029 (SCI). (Impact factor: 2.413;Rank: 56.77%)第一或通訊作者
  22. Lee CW, Leu SJ, Tzeng RY, Wang SF, Tsai SC, Sun KH, Chen RH, Huang JC.. Latent membrane protein 1 of Epstein-Barr virus regulates death-associated protein kinase 1 in lymphoblastoid cell line . VIROLOGY 2011; 413(1):19-25 (SCI). (Impact factor: 3.374;Rank: 35.71%)第四或以後作者
  23. Tai-Ping Lee, Shye-Jye Tang, Ming-Fang Wu, Ying-Chyi Song, Chia-Li Yu, Kuang-Hui Sun. Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes. JOURNAL OF AUTOIMMUNITY 2010; 35:358-367 (SCI). (Impact factor: 7.607;Rank: 9.35%)第一或通訊作者
  24. Ying-Chyi Song, Shye-Jye Tang, Tai-Ping Lee, Wen-Chien Hung, Shu-Chi Lin, Chang-Youh Tsai, Wailap Victor Ng, Ming-Fang Wu, Kuang-Hui Sun.. Reversing interleukin-2 inhibition mediated by anti-dsDNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice. ARTHRITIS AND RHEUMATISM 2010; 62:2401-2411 (SCI). (Impact factor: 8.955;Rank: 7.81%)第一或通訊作者
  25. Ming-Yi Ho, Shye-Jye Tang, Wailap Victor Ng,Winnie Yang, Shr-Jeng Jim Leu, Ying-Chun Lin, Chi-Kuang Feng, Jung-Sung Sung, Kuang-Hui Sun. The nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing cyclooxygenase 2 expression. Cancer science 2010; 101(11):2411-6 (SCI). (Impact factor: 4.372;Rank: 29.37%)第一或通訊作者
  26. Tai-Ping Lee, Shr-Jeng Jim Leu, Jason C. Huang, Ying-Chyi Song, Ren-Shiang Jhou, Shye-Jye Tang and Kuang-Hui Sun. Anti-ribosomal P autoantibody triggers IL-10 over-production via PI3K-dependent signaling pathways in LPS-activated macrophages. Immunology 2009; 127:91-102 (SCI). (Impact factor: 3.358;Rank: 44.84%)第一或通訊作者
  27. Ming-Yi Ho, Shr-Jeng Jim Leu, Guang-Huan Sun, Mi-Hua Tao, Shye-Jye Tang, Kuang-Hui Sun. IL-27 Directly Restrains Lung Tumorigenicity by Suppressing Cyclooxygenase-2-Mediated Activities. JOURNAL OF IMMUNOLOGY 2009; 183 :6217–6226. (SCI). (Impact factor: 4.539;Rank: 24.84%)第一或通訊作者
  28. Ren-Shiang Jhou, Kuang-Hui Sun, Guang-Huan Sun, Hsiao-Hsien Wang, Chung-I Chang, Hsiao-Chun Huang, Shou-Yun Lu, and Shye-Jye Tang. Inhibition of cyclin-dependent kinases by Olomoucine and Roscovitine reduces lipopolysaccharide-induced inflammatory Responses via down-Regulation of nuclear factor kB. Cell Proliferation 2009; 42:141-149 (SCI). (Impact factor: 4.936;Rank: 27.11%)第二作

  29. Ming-Yi Ho , Guang-Huan Sun , Shr-Jeng Jim Leu , Shuk-Man Ka , Shye-Jye Tang , and Kuang-Hui Sun. Combination of FasL and GM-CSF Confers Synergistic Antitumor Immunity in an In Vivo Model of the Murine Lewis Lung Carcinoma. International Journal of Cancer 2008; 123:123-133 (SCI). (Impact factor: 7.36;Rank: 10.09%)第一或通訊作者

  30. Shye-Jye Tang, Ming-Yi Ho, Huan-Chieh Cho, Ying-Chun Lin, Guang-Huan Sun, Kwan-Hwa Chi, Yu-Shan Wang, Ren-Shiang Jhou, Winnie Yang, and Kuang-Hui Sun. Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo . INTERNATIONAL JOURNAL OF CANCER 2008; 123 :2840–2848 (SCI). (Impact factor: 7.36;Rank: 10.09%)第一或通訊作者

  31. Mei-Jen, Chuang, Kuang-Hui Sun, Shye-Jye Tang, Ming-Wei Deng, Yu-Hsin Wu, Jung-Sung Sung, Tai-Lung Cha and Guang-Huan Sun. Tumor-derived TNF-α promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells. Cancer Science 2008; 99:905-913 (SCI). (Impact factor: 4.372;Rank: 29.37%)第二作者

  32. Hsing-Hui Li, He-Hsiung Cheng, Kuang-Hui Sun, Chi-Chen Wei,Chien-Feng Li, Wen-Chung Chen, Wen-Mein Wu, Ming-Shi Chang.. Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. CLINICAL IMMUNOLOGY 2008; 129:277-85 (SCI). (Impact factor: 3.557;Rank: 38.39%)第三作者

  33. Ying-Chyi Song, Guang-Huan Sun, Tai-Ping Lee, Jason C. Huang, Chia-Li Yu, Chia-Hung Chen, Shye-Jye Tang, Kuang-Hui Sun.. Arginines in the CDR of Anti-dsDNA Autoantibodies facilitate cell internalization via electrostatic interactions. EUROPEAN JOURNAL OF IMMUNOLOGY 2008; 38(11):3178-90. (SCI). (Impact factor: 4.248;Rank: 28.06%)第一或通訊作者
  34. Hui-Ying Luan, Shye-Jye Tang, Winnie Yang, Chang-Youh Tsai, Guang-Huan Sun, Kuang-Hui Sun.. Monoclonal anti-DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line . Clinical Immunology 2006; 120:326-334 (SCI). (Impact factor: 3.557;Rank: 38.39%)第一或通訊作者
  35. Kuang-Hui Sun, Hsiao-Yi Lin Lee-Wen Chen, Hsiao-Yun Tai, Mei-Lin Lin,Chi-Kuang Feng, Jung-Sung Sung, Hsin-Fu Liu, Wu-Tse Liu. Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases. Clinical Rheumatology 2006; 25:694-699 (SCI). (Impact factor: 2.141;Rank: 68.33%)第一或通訊作者
  36. Kuang-Hui Sun, Shye-Jye Tang, Chau-Yaun Chen, Tai-Ping Lee, Chi-Kuang Feng, Chia-Li Yu, Guang-Huan Sun. Monoclonal ribosomal P autoantibody inhibits the expression and release of IL-12, TNF-α and iNOS in activated RAW macrophage cell line. Journal of Autoimmunity 2005; 24:135-143 (SCI). (Impact factor: 7.607;Rank: 9.35%)第一或通訊作者
  37. Kuang-Hui Sun, Guang-Huan Sun, Chang-Youh Tsai, Hsiao-Hsien Wang, Chung-I Chang, Guang Lin, Wen-Wen Lin, Shye-Jye Tang. Expression, purification, refolding, and characterization of recombinant human soluble-Fas ligand from Escherichia coli. Enzyme and Microbial Technology 2005; 36:527-534 (SCI). (Impact factor: 2.932;Rank: 33.23%)第一或通訊作者
  38. Kuang-Hui Sun, Guang-Huan Sun, Yeu Su, Chung-I Chang, Mei-Chen Chuang, Wan-Lin Wu, Chia-Yi Chu, Shye-Jye Tang. Acidic-rich region of amyloid precursor protein induces glial cell apoptosis. Apoptosis 2004; 9:833-841 (SCI). (Impact factor: 3.967;Rank: 26.11%)第一或通訊作者
  39. Sun KH, Tang SJ, Wang YS, Lin WJ, You RI,. Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2. Rheumatology 2003; 2(:154-161 (SCI). (Impact factor: 5.245;Rank: 15.00%)第一或通訊作者
  40. Tang SJ, Sun KH, Sun GH, Chang TY, Wu WL, Lee GC. A transformation system for the nonuniversal CUG(Ser) codon usage species Candida rugosa. Journal of Microbiological Methods 2003; 52:231-238 (SCI). (Impact factor: 1.701;Rank: 71.52%)第二作者
  41. Hsieh SC, Yu HS, Lin WW, Sun KH, Tsai CY, Huang DF, Tsai YY, Yu CL. Anti-SSB/La is one of the antineutrophil autoantibodies responsible for neutropenia and functional impairment of polymorphonuclear neutrophils in patient with systemic lupus erythenatosus. Clinical and Experimental Immunology 2003; 131:506-516 (SCI). (Impact factor: 3.542;Rank: 40.32%)第四或以後作者
  42. Yu CL, Yu HS, Sun KH, Hsieh SC, Tsai CY. Anti-CD45 isoform antibodies enhance phagocytosis and gene expression of IL-8 and TNF-a in human neutrophils by differential suppression on protein tyrosine phosphorylation and p56lck tyrosine kinase. Clinical and Experimental Immunology 2002; 129:78-85 (SCI). (Impact factor: 3.542;Rank: 40.32%)第三作者
  43. Yu CL, Sun KH, Tsai CY, Hsieh SC, Yu HS.. Anti-dsDNA antibody up-regulates interleukin 6, but not cyclooxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage?. Inflammation Research 2001; 50:12-18 (SCI). (Impact factor: 2.99;Rank: 53.23%)第二作者
  44. Sun KH, Tang SJ, Lin ML, Wang YS, Sun GH, Liu WT. Monoclonal antibodies against human ribosomal P proteins penetrate into living cells and cause apoptosis of Jurkat T cells in culture. Rheumatology 2001; 40:750-756 (SCI). (Impact factor: 5.245;Rank: 15.00%)第一或通訊作者
  45. Hsieh SC, Sun KH, Tsai CY, Tsai YY, Tsai ST, Huang DF, Han SH, Yu HS, Yu CL. Monoclonal anti-double stranded DNA antibody is a leukocyte binding protein to up-regulate IL-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils. Rheumatology 2001; 40:851-858 (SCI). (Impact factor: 5.245;Rank: 15.00%)第二作者
  46. Tang SJ, Shaw JF, Sun KH, Sun GH, Chang TY, Lin CK, Lo YC, Lee GC,. Recombinant expression and characterization of the Candida rugosa lip4 lipase in Pichia pastoris: Comparison of glycosylation, activity, and stability. Archives of Biochemistry and Biophysics 2001; 387:93-98 (SCI). (Impact factor: 3.118;Rank: 32.64%)第三作者
  47. Tai HY, Sun KH, Kung SH, Liu WT. A quantitative assay for measuring human foamy virus using an established indicator cell line. Journal of Virological Methods 2001; 94:155-162 (SCI). (Impact factor: 1.756;Rank: 64.29%)第二作者
  48. Sun KH, Yu CL, Tang SJ, Sun GH. Monoclonal anti-double stranded-DNA autoantibody stimulates the expression and release of IL-1β, IL-6, IL-8, IL-10 and TNF-α from normal human mononuclear cells involving the lupus pathogenesis. Immunology 2000; 99:352-360 (SCI). (Impact factor: 3.358;Rank: 44.84%)第一或通訊作者
  49. Tang SJ, Sun KH, Sun GH, Chang TY, Lee GC. Recombinant expression of the Candida rugosa LIP4 lipase in Escherichia coli. Protein Expression and Purification 2000; 20:308-313 (SCI). (Impact factor: 1.338;Rank: 78.57%)第二作者
  50. Sun KH, Hong CC, Tang SJ, Sun GH, Liu WT, Han SH, Yu CL. Anti-dsDNA autoantibody cross-reacts with C-terminal hydrophobic cluster region containing phenylalanines in the acidic ribosomal phosphoprotein P1 to exert a cytostatic effect on the cells. Biochemical and Biophysical Research Communications 1999; 263:334-339 (SCI). (Impact factor: 2.559;Rank: 47.92%)第一或通訊作者
  51. Tang SJ, Sun KH, Sun GH, Lin G, Lin WW, Chuang MJ. Cold-induced ependymin expression in zebrafish and carp brain: Implication for cold acclimation. FEBS Letters 1999; 459:95-99 (SCI). (Impact factor: 2.999;Rank: 38.19%)第二作者
  52. Lee GC, Tang SJ, Sun KH, Shaw JF. Analysis of the gene family encoding lipases in Candida rugosa by competitive reverse transcription-PCR. Applied and Environmental Microbiology 1999; 65:3888-3895 (SCI). (Impact factor: 3.633;Rank: 25.16%)第三作者