{"id":298,"date":"2021-03-25T01:48:03","date_gmt":"2021-03-25T01:48:03","guid":{"rendered":"http:\/\/dmt.nycu.edu.tw\/?page_id=298"},"modified":"2026-10-06T08:10:14","modified_gmt":"2026-10-06T00:10:14","slug":"%e6%b6%82%e7%8e%89%e9%9d%92","status":"publish","type":"page","link":"https:\/\/dmt.nycu.edu.tw\/en\/%e6%b6%82%e7%8e%89%e9%9d%92\/","title":{"rendered":"\u6d82\u7389\u9752"},"content":{"rendered":"
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

\u6d82\u7389\u9752\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Yuh-Ching Twu<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

\u806f\u7d61\u65b9\u5f0f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u53f0\u5317\u5e02\u5317\u6295\u5340\u77f3\u724c\u7acb\u8fb2\u8857\u4e8c\u6bb5155\u865f \u751f\u91ab\u5de5\u7a0b\u9928 205\u5ba4
\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7cfb
\u96fb\u5b50\u90f5\u4ef6: yctwu@nycu.edu.tw<\/p>

\u96fb\u8a71: 02-2826-7294 (Office)
02-2826-7000 ext. 65831 (Lab) <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t

\u5b78\u6b77<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 \u535a\u58eb\u00a0 (2003.9~2008.1)<\/p>

\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7814\u7a76\u6240 \u78a9\u58eb (1997.9~1999.8)<\/p>

\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u6280\u8853\u5b78\u7cfb \u5b78\u58eb (1993.9~1997.6)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t

\u6388\u8ab2\u79d1\u76ee<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u8840\u5eab\u5b78\u3001\u8840\u6db2\u5b78\u8207\u81e8\u5e8a\u8840\u6db2\u5b78\u3001\u91a3\u8cea\u751f\u7269\u5b78\u3001\u8840\u6db2\u5b78\u53ca\u8840\u5eab\u5b78\u5be6\u9a57<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

\u5b78\u6b77<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 \u535a\u58eb (2003.9~2008.1)
\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7814\u7a76\u6240 \u78a9\u58eb (1997.9~1999.8)
\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u6280\u8853\u5b78\u7cfb \u5b78\u58eb (1993.9~1997.6)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

\u7d93\u6b77<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u526f\u6559\u6388 \u967d\u660e\u4ea4\u901a\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u6aa2\u9a57\u5b78\u7cfb(2017.8~2023.7)
\u52a9\u7406\u6559\u6388 \u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u6aa2\u9a57\u5b78\u7cfb(2012.8~2017.7)
\u535a\u58eb\u5f8c\u7814\u7a76 Terry Fox Laboratory, BC Cancer Agency, Canada (2011.7~2012.7)
\u535a\u58eb\u5f8c\u7814\u7a76 Department of Microbiology and Immunology, University of British Columbia, Canada (2008.11~2011.6)
\u535a\u58eb\u5f8c\u7814\u7a76 \u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 (2008.2~2008.10) <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

\u7814\u7a76\u65b9\u5411<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u00a0 \u00a0\u91a3\u5316\u4f5c\u7528\uff08glycosylation\uff09\u662f\u7d30\u80de\u91cd\u8981\u7684\u5f8c\u8f49\u8b6f\u4fee\u98fe\u3002\u7d30\u80de\u8868\u9762\u91a3\u5206\u5b50\u53ef\u900f\u904e\u8207\u91a3\u53d7\u9ad4\u53ca\u5176\u4ed6\u914d\u9ad4\u4e92\u52d5\uff0c\u8abf\u63a7\u7d30\u80de\u8a0a\u606f\u50b3\u905e\u3001\u589e\u751f\u3001\u5206\u5316\u3001\u764c\u5316\u3001\u514d\u75ab\u8fa8\u8b58\u8207\u514d\u75ab\u76e3\u63a7\u3002\u816b\u7624\u8207\u767d\u8840\u75c5\u7d30\u80de\u5e38\u51fa\u73fe\u816b\u7624\u76f8\u95dc\u91a3\u985e\u6297\u539f\uff08tumor-associated carbohydrate antigens, TACAs\uff09\u53ca\u7570\u5e38\u553e\u6db2\u9178\u5316\uff08hypersialylation\uff09\uff0c\u4e26\u53ef\u80fd\u85c9\u7531\u7d50\u5408\u514d\u75ab\u7d30\u80de\u4e0a\u7684\u553e\u6db2\u9178\u7d50\u5408\u514d\u75ab\u7403\u86cb\u767d\u6a23\u51dd\u96c6\u7d20\uff08sialic acid-binding immunoglobulin-like lectins, Siglecs\uff09\uff0c\u524a\u5f31\u514d\u75ab\u7d30\u80de\u7684\u8fa8\u8b58\u8207\u6548\u61c9\u529f\u80fd\uff0c\u5f62\u6210\u514d\u75ab\u9003\u812b\u3002<\/p>

\u672c\u7814\u7a76\u5718\u968a\u4ee5 Siglec-7 \u70ba\u6838\u5fc3\uff0c\u63a2\u8a0e\u7d30\u80de\u8868\u9762\u91a3\u7d50\u69cb\u3001\u514d\u75ab\u53d7\u9ad4\u8a0a\u865f\u3001\u7c92\u7dda\u9ad4\u529f\u80fd\u8207\u7d30\u80de\u4ee3\u8b1d\u4e4b\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u7814\u7a76\u4e3b\u8ef8\u5305\u62ec\uff1a<\/p>

  1. \u7d30\u80de\u8868\u9762\u91a3\u4fee\u98fe\u8207\u81ea\u7136\u6bba\u624b\u7d30\u80de\u514d\u75ab\u76e3\u63a7
    \u63a2\u8a0e\u816b\u7624\u53ca\u767d\u8840\u75c5\u7d30\u80de\u7684\u91a3\u93c8\u3001\u553e\u6db2\u9178\u5316\u8207 Siglec-7 \u914d\u9ad4\u5982\u4f55\u5f71\u97ff\u81ea\u7136\u6bba\u624b\u7d30\u80de\uff08natural killer cells, NK cells\uff09\u7684\u8fa8\u8b58\u3001\u53bb\u9846\u7c92\u3001\u7d30\u80de\u6bd2\u6027\u53ca\u7d30\u80de\u6fc0\u7d20\u5206\u6ccc\u3002<\/li>
  2. Siglec-7 \u8abf\u63a7 NK \u7d30\u80de\u7c92\u7dda\u9ad4\u8207\u4ee3\u8b1d
    \u7814\u7a76 Siglec-7 \u5982\u4f55\u9023\u7d50\u7c92\u7dda\u9ad4\u5206\u88c2\u8207\u878d\u5408\u3001\u6c27\u5316\u78f7\u9178\u5316\u3001\u80fd\u91cf\u4ee3\u8b1d\u53ca\u4ee3\u8b1d\u91cd\u7de8\u7a0b\uff0c\u9032\u800c\u9650\u5236\u4eba\u985e NK \u7d30\u80de\u7684\u7d30\u80de\u6bd2\u6027\u529f\u80fd\u3002<\/li>
  3. Siglec-7 \u8207\u5de8\u6838\u7d30\u80de\u751f\u6210\u53ca\u8840\u5c0f\u677f\u751f\u6210
    \u63a2\u8a0e Siglec-7 \u5728\u5de8\u6838\u7d30\u80de\u751f\u6210\uff08megakaryopoiesis\uff09\u8207\u8840\u5c0f\u677f\u751f\u6210\uff08thrombopoiesis\uff09\u4e2d\u7684\u8868\u73fe\u3001\u529f\u80fd\u53ca\u5176\u8207\u7c92\u7dda\u9ad4\u52d5\u529b\u5b78\u7684\u95dc\u806f\uff0c\u89e3\u6790\u5176\u5728\u5de8\u6838\u7d30\u80de\u5206\u5316\u3001\u8840\u5c0f\u677f\u751f\u6210\u53ca\u8840\u5c0f\u677f\u529f\u80fd\u4e2d\u7684\u751f\u7406\u4f5c\u7528\u3002<\/li>
  4. \u9020\u8840\u7d30\u80de\u5206\u5316\u8207\u8840\u6db2\u816b\u7624
    \u4ee5\u7d05\u8840\u7403\u751f\u6210\u3001\u5de8\u6838\u7d30\u80de\u5206\u5316\u3001\u767d\u8840\u75c5\u7d30\u80de\u53ca NK \u7d30\u80de\u70ba\u7814\u7a76\u6a21\u578b\uff0c\u89e3\u6790\u91a3\u93c8\u4fee\u98fe\u3001\u8f49\u9304\u8207\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u3001\u7c92\u7dda\u9ad4\u4ee3\u8b1d\u53ca\u514d\u75ab\u6548\u61c9\u4e4b\u9593\u7684\u5206\u5b50\u6a5f\u5236\u3002<\/li>
  5. \u91a3\u985e\u6a19\u8a8c\u8207\u8f49\u8b6f\u61c9\u7528
    \u767c\u5c55\u53ef\u7528\u65bc\u8a55\u4f30\u514d\u75ab\u7d30\u80de\u529f\u80fd\u3001\u816b\u7624\u514d\u75ab\u9003\u812b\u3001\u8840\u6db2\u75be\u75c5\u53ca\u8840\u5c0f\u677f\u751f\u7269\u5b78\u7684\u91a3\u985e\u8207 Siglec-7 \u76f8\u95dc\u5206\u5b50\u6a19\u8a8c\uff0c\u4e26\u63a2\u7d22\u5176\u5728\u75be\u75c5\u5206\u5c64\u3001\u9810\u5f8c\u8a55\u4f30\u53ca\u514d\u75ab\u6cbb\u7642\u7b56\u7565\u4e2d\u7684\u61c9\u7528\u6f5b\u529b\u3002<\/li><\/ol>

    \u6574\u9ad4\u7814\u7a76\u65b9\u5411\u805a\u7126\u65bc\u300c\u91a3\u5316\u4f5c\u7528\u2014Siglec-7\u2014\u7c92\u7dda\u9ad4\u2014\u514d\u75ab\u8207\u9020\u8840\u529f\u80fd\u300d\u4e4b\u6574\u5408\u6027\u6a5f\u5236\uff0c\u671f\u671b\u95e1\u660e\u7d30\u80de\u8868\u9762\u91a3\u8a0a\u865f\u5982\u4f55\u8f49\u5316\u70ba\u7c92\u7dda\u9ad4\u8207\u4ee3\u8b1d\u53cd\u61c9\uff0c\u9032\u800c\u8abf\u63a7\u514d\u75ab\u7d30\u80de\u6548\u61c9\u53ca\u9020\u8840\u7d30\u80de\u5206\u5316\u3002<\/p>

    Research Interests<\/u><\/p>

    Glycosylation is an important post-translational modification that regulates a wide range of cellular processes. Cell-surface glycans interact with glycan-binding receptors and other ligands to modulate intracellular signaling, cell proliferation, differentiation, oncogenic transformation, immune recognition, and immune surveillance. Tumor and leukemia cells frequently exhibit tumor-associated carbohydrate antigens (TACAs) and aberrant hypersialylation. Through interactions with sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed on immune cells, these altered glycan structures may attenuate immune recognition and effector functions, thereby contributing to immune evasion.<\/p>

    Our research focuses on Siglec-7 and investigates the interplay among cell-surface glycan structures, immune-receptor signaling, mitochondrial function, and cellular metabolism. Major research areas include:<\/p>

    1. Cell-surface glycosylation and natural killer cell immune surveillance
      We investigate how glycan structures, sialylation, and Siglec-7 ligands on tumor and leukemia cells regulate natural killer (NK) cell recognition, degranulation, cytotoxicity, and cytokine production.<\/li>
    2. Siglec-7 regulation of mitochondrial function and metabolism in NK cells
      We study how Siglec-7 connects mitochondrial fission and fusion, oxidative phosphorylation, energy metabolism, and metabolic reprogramming to restrain the cytotoxic function of human NK cells.<\/li>
    3. Siglec-7 in megakaryopoiesis and thrombopoiesis
      We investigate the expression and function of Siglec-7 during megakaryopoiesis and thrombopoiesis, with particular emphasis on its relationship with mitochondrial dynamics and its physiological roles in megakaryocytic differentiation, platelet production, and platelet function.<\/li>
    4. Hematopoietic differentiation and hematological malignancies
      Using models of erythropoiesis, megakaryocytic differentiation, leukemia, and NK-cell biology, we examine the molecular mechanisms linking glycan remodeling, transcriptional and epigenetic regulation, mitochondrial metabolism, and immune effector functions.<\/li>
    5. Glycan-related biomarkers and translational applications
      We aim to identify glycan- and Siglec-7-related molecular biomarkers for evaluating immune-cell function, tumor immune evasion, hematological disorders, and platelet biology, and to explore their potential applications in disease stratification, prognostic assessment, and immunotherapeutic development.<\/li><\/ol>

      Overall, our research centers on the integrated glycan\u2013Siglec-7\u2013mitochondria\u2013immune and hematopoietic function axis. We seek to clarify how cell-surface glycan signals are translated into mitochondrial and metabolic responses that regulate immune-cell effector functions and hematopoietic-cell differentiation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

      \n\t\t\t\t\t\t
      \n\t\t\t\t\t
      \n\t\t\t
      \n\t\t\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t

      \u7814\u7a76\u8457\u4f5c<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t\t\t\t\t
      1. Su SC, Tsao NT, Wang TL, Shih YC, Twu YC<\/u><\/strong>. Siglec-7 orchestrates mitochondrial dynamics and metabolic reprogramming to restrain human NK cell cytotoxic function. Journal of Biological Chemistry. Published online September 8, 2026. Article 113543. doi: 10.1016\/j.jbc.2026.113543.<\/li>
      2. Lin SM, Wu S, Yu LC, Twu YC<\/strong>. Siglec-7 links mitochondrial dynamics to megakaryocytic differentiation. Stem Cells and Development. 2026;35(5\u20136):103\u2013109. Published online February 16, 2026. doi: 10.1177\/15473287261423853.<\/li>
      3. Lin SM, Yen HS, Lin YH, Twu YC<\/strong>. DNA methylation inhibition modulates Siglec-7 and surface receptors expression to boost NK cytotoxicity. Journal of Biomedical & Laboratory Sciences. 2026;38(4).<\/li>
      4. Lin SM, Yen HS, Lin YH, Twu YC<\/strong>. IL-12\/15\/18 enhanced NK cytotoxicity likely via downregulated Siglec-7 in NK-92MI-S cells. Journal of Biomedical & Laboratory Sciences. 2026;38(4).<\/li>
      5. Teng HW, Huang HY, Lin CC, Twu YC<\/strong>, Yang WH, Lin WC, Lan HY, Lin YY, Hwang WL. CT45A1-mediated MLC2 (MYL9) phosphorylation promotes natural killer cell resistance and outer cell fate in a cell-in-cell structure, potentiating the progression of microsatellite instability-high colorectal cancer.<\/em> Molecular Oncology<\/em>. 2025;19(2):430\u2013451.<\/li>
      6. Wu IW, Chang LC, Wu YL, Yang HY, Twu YC<\/strong>, Tsai PY, Paulus S, Resnick R, Chung WH, Yang CW, Hsieh WP, Su SC. Gut flora metagenomic analysis coupled with metabolic and deep immune profiling in chronic kidney disease.<\/em> Nephrology Dialysis Transplantation<\/em>. 2024;39(8):1333\u20131343.<\/li>
      7. Huang YF, Su SC, Chuang HY, Chen HH, Twu YC. Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. Journal of Thrombosis and Haemostasis. 2023;21:329\u2013343.<\/li>
      8. \u6797\u5abd\u5229\uff08\u7e3d\u6821\u95b1\uff09\u3001\u6731\u6b63\u4e2d\u3001\u6731\u82b3\u696d\u3001\u674e\u4fca\u5104\u3001\u4f59\u69ae\u71be\u3001\u4f55\u570b\u7dad\u3001\u6797\u51a0\u5dde\u3001\u6797\u60e0\u6dd1\u3001\u6797\u5c0a\u6e44\u3001\u6d2a\u82f1\u8056\u3001\u5b6b\u5efa\u5cf0\u3001\u6d82\u7389\u9752<\/strong>\u3001\u5f35\u5c0f\u7433\u3001\u5f35\u5fd7\u6607\u3001\u5f35\u5efa\u570b\u3001\u5f35\u9cf3\u5a1f\u3001\u9673\u5b9a\u5e73\u3001\u9673\u6dd1\u60e0\u3001\u9673\u7005\u5982\u3001\u7a0b\u4ec1\u5049\u3001\u9ec3\u4ef0\u4ef0\u3001\u694a\u5b5f\u6a3a\u3001\u694a\u570b\u6881\u3001\u842c\u7965\u9e9f\u3001\u8449\u5ead\u5409\u3001\u8a79\u8a60\u7d6e\u3001\u5289\u5927\u667a\u3001\u9ece\u857e\u3001\u95d5\u5b97\u7199\u3001\u7f85\u4ed5\u9321\u3002\u300a\u8f38\u8840\u91ab\u5b78\u300b\u7b2c\u516d\u7248\u3002\u4e94\u5357\u51fa\u7248\u793e\uff1b2023\u3002<\/li>
      9. Yeh YL, Tsao NT, Twu YC<\/strong>. Siglec-7 status modulates memory-like cytotoxicity in leukemia-primed human natural killer cells. Journal of Biomedical & Laboratory Sciences. 2023;35:56\u201363.<\/li>
      10. Liao YJ, Lee CY, Twu YC<\/strong>, Suk FM, Lai TC, Chang YC, Lai YC, Yuan JW, Jhuang HM, Jian HR, Huang LC, Chen KP, Hsu MH. Isolation and biological evaluation of alfa-mangostin as potential therapeutic agents against liver fibrosis.<\/em> Bioengineering<\/em>. 2023;10(9):1075. doi: 10.3390\/bioengineering10091075<\/li>
      11. Lin WC, Lin CC, Lin YY, Yang WH, Twu YC<\/strong>, Teng HW, Hwang WL. Molecular actions of exosomes and their theragnostic in colorectal cancer: current findings and limitation. Cellular Oncology. 2022;45:1043\u20131052.<\/li>
      12. Wu IW, Wu YL, Yang HY, Hsu CK, Chang LC, Twu YC<\/strong>, Chang YL, Chung WH, Yang CW, Hsieh WP, Su SC. Deep immune profiling of patients with renal impairment unveils distinct immunophenotypes associated with disease severity. Clinical Kidney Journal. 2022.<\/li>
      13. Wu YX, Lu HF, Lin YH, Chuang HY, Su SC, Liao YJ, Twu YC<\/strong>. Branched I antigen regulated cell susceptibility against natural killer cell cytotoxicity through its N-linked glycosylation and overall expression. Glycobiology. 2021;31:624\u2013635.<\/li>
      14. \u4f59\u69ae\u71be\u3001\u738b\u660c\u73b2\u3001\u6731\u6b63\u4e2d\u3001\u6731\u5fd7\u82ac\u3001\u6731\u82b3\u696d\u3001\u4f55\u570b\u7dad\u3001\u6797\u51a0\u5dde\u3001\u6797\u5abd\u5229\u3001\u6d82\u7389\u9752<\/strong>\u3001\u5f35\u5c0f\u7433\u3001\u5f35\u9cf3\u5a1f\u3001\u9673\u5b9a\u5e73\u3001\u9673\u5180\u5bec\u3001\u9673\u7005\u5982\u3001\u9678\u4e2d\u8861\u3001\u9ec3\u4ef0\u4ef0\u3001\u694a\u5b5f\u6a3a\u3001\u842c\u7965\u9e9f\u3001\u8a79\u8a60\u7d6e\u3001\u8521\u6b23\u6021\u3001\u9ece\u857e\u3001\u7f85\u4ed5\u9321\u3002\u300a\u8f38\u8840\u91ab\u5b78\u300b\u7b2c\u4e94\u7248\u3002\u4e94\u5357\u51fa\u7248\u793e\uff1b2021\u3002<\/li>
      15. Lee CY, Suk FM, Twu YC<\/strong>, Liao YJ. Long-term exposure to low-dose di-(2-ethylhexyl) phthalate impairs cholesterol metabolism in hepatic stellate cells and exacerbates liver fibrosis. International Journal of Environmental Research and Public Health. 2020;17:3802.<\/li>
      16. Huang HT, Su SC, Chiou TJ, Lin YH, Shih YJ, Wu YX, Fan TH, Twu YC. DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5\u2032 promoter CpG sites. Immunology. 2020;160:38\u201351.<\/li>
      17. Wang YH, Liu CL, Chiu WC, Twu YC<\/strong>, Hsu MH, Liao YJ. Antifibrotic effects of a barbituric acid derivative on liver fibrosis by blocking the NF-\u03baB signaling pathway in hepatic stellate cells. Frontiers in Pharmacology. 2020;11:388.<\/li>
      18. Wang YH, Suk FM, Liu CL, Chen TL, Twu YC, Hsu MH, Liao YJ. HMGCS2 mediates ketone production and regulates the proliferation and metastasis of hepatocellular carcinoma. Cancers. 2019;11:1876.<\/li>
      19. Huang CH, Liao YJ, Chiou TJ, Huang HT, Lin YH, Twu YC<\/strong>. TGF-\u03b2 regulated leukemia cell susceptibility against NK targeting through the down-regulation of CD48 expression. Immunobiology. 2019;224:649\u2013658.<\/li>
      20. Wang YH, Twu YC<\/strong>, Wang CK, Lin FZ, Lee CY, Liao YJ. Niemann-Pick type C2 protein regulates free cholesterol accumulation and influences hepatic stellate cell proliferation and mitochondrial respiration function. International Journal of Molecular Sciences. 2018;19.<\/li>
      21. Yeh CC, Chang CJ, Twu YC<\/strong>, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, Yu LC. The molecular genetic background leading to formation of the human erythroid-specific Xga\/CD99 blood groups. Blood Advances. 2018;2:1854\u20131864.<\/li>
      22. Huang CH, Liao YJ, Fan TH, Chiou TJ, Lin YH, Twu YC<\/strong>. A developed NK-92MI cell line with Siglec-7neg phenotype exhibits high and sustainable cytotoxicity against leukemia cells. International Journal of Molecular Sciences. 2018;19.<\/li>
      23. Yeh CC, Chang CJ, Twu YC<\/strong>, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, Yu LC. The differential expression of the blood group P1-A4GALT and P2-A4GALT alleles is stimulated by the transcription factor early growth response 1. Transfusion. 2018;58:1054\u20131064.<\/li>
      24. Lee YH, Liao YJ, Huang CH, Chang FL, Fan TH, Twu YC<\/strong>. Branched I antigens on leukemia cells enhanced sensitivity against NK cytotoxicity through affecting the target-effector interaction. Transfusion. 2017;57:1040\u20131051.<\/li>
      25. Hsu MH, Hsu SM, Kuo YC, Liu CY, Hsieh CY, Twu YC<\/strong>, Wang CK, Wang YH, Liao YJ. Treatment with low-dose sorafenib in combination with a novel benzimidazole derivative bearing a pyrrolidine side chain provides synergistic anti-proliferative effects against human liver cancer. RSC Advances. 2017;7:16253\u201316263.<\/li>
      26. Liao YJ, Lee YH, Chang FL, Ho H, Huang CH, Twu YC<\/strong>. The SHP-2\u2013ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of C\/EBP\u03b1 to the IGnTC promoter region during erythroid differentiation. Transfusion. 2016;56:2691\u20132702.<\/li>
      27. Liao YJ, Lee TS, Twu YC<\/strong>, Hsu SM, Yang CP, Wang CK, Liang YC, Chen YM. Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K\/Akt pathway in the liver. Journal of Biomedical Science. 2016;23:69.<\/li>
      28. Twu YC<\/strong>, Lee TS, Lin YL, Hsu SM, Wang YH, Liao CY, Wang CK, Liang YC, Liao YJ. Niemann-Pick type C2 protein mediates hepatic stellate cell activation by regulating free cholesterol accumulation. International Journal of Molecular Sciences. 2016;17:1\u201312.<\/li>
      29. Twu YC<\/strong>, Teh HS. The ThPOK transcription factor differentially affects the development and function of self-specific CD8+ T cells and regulatory CD4+ T cells. Immunology. 2014;141:431\u2013445.<\/li>
      30. Twu YC<\/strong>, Gold MR, Teh HS. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells. European Journal of Immunology. 2011;41:335\u2013344.<\/li>
      31. Twu YC<\/strong>, Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC. Phosphorylation status of transcription factor C\/EBP\u03b1 determines cell-surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. Blood. 2010;115:2491\u20132499.<\/li>
      32. Wang HR, Hsieh CY, Twu YC<\/strong>, Yu LC. Expression of the human Sd(a) \u03b2-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status. Glycobiology. 2008;18:104\u2013113.<\/li>
      33. Twu YC<\/strong>, Chen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC. I branching formation in erythroid differentiation is regulated by transcription factor C\/EBP\u03b1. Blood. 2007;110:4526\u20134534.<\/li>
      34. Twu YC<\/strong>, Hsieh CY, Yu LC. Expression of the histo-blood group B gene predominates in AB-genotype cells. Transfusion. 2006;46:1988\u20131996.<\/li>
      35. Lin M, Hou MJ, Twu YC<\/strong>, Yu LC. A novel A allele with 664G>A mutation identified in a family with the Am phenotype. Transfusion. 2005;45:63\u201369.<\/li>
      36. Yu LC, Twu YC<\/strong>, Chou ML, Reid ME, Gray AR, Moulds JM, Chang CY, Lin M. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. Blood. 2003;101:2081\u20132088.<\/li>
      37. Twu YC<\/strong>, Chou ML, Yu LC. The molecular genetics of the mouse I \u03b2-1,6-N-acetylglucosaminyltransferase locus. Biochemical and Biophysical Research Communications. 2003;303:868\u2013876.<\/li>
      38. Sun CF, Yu LC, Chen IP, Chou DL, Twu YC<\/strong>, Wang WT, Lin M. Molecular genetic analysis for the Ae1 and A3 alleles. Transfusion. 2003;43:1138\u20131144.<\/li>
      39. Yu LC, Twu YC<\/strong>, Chou ML, Chang CY, Wu CY, Lin M. Molecular genetic analysis for the B(3) allele. Blood. 2002;100:1490\u20131492.<\/li>
      40. Yu LC, Twu YC<\/strong>, Chang CY, Lin M. Molecular basis of the Kell-null phenotype: a mutation at the splice site of human KEL gene abolishes the expression of Kell blood group antigens. Journal of Biological Chemistry. 2001;276:10247\u201310252.<\/li>
      41. Yu LC, Twu YC<\/strong>, Chang CY, Lin M. Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen. Blood. 2001;98:3840\u20133845.<\/li>
      42. Yu LC, Chu CC, Chan YS, Chang CY, Twu YC<\/strong>, Lee HL, Lin M. Polymorphism and distribution of the Secretor \u03b1(1,2)-fucosyltransferase gene in various Taiwanese populations. Transfusion. 2001;41:1279\u20131284.<\/li>
      43. Yu LC, Chang CY, Twu YC<\/strong>, Lin M. Human histo-blood group ABO glycosyltransferase genes: different enhancer structures with different transcriptional activities. Biochemical and Biophysical Research Communications. 2000;273:459\u2013466.<\/li>
      44. Hsu HY, Twu YC<\/strong>. Tumor necrosis factor-\u03b1-mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. Journal of Biological Chemistry. 2000;275:41035\u201341048.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

        \u6d82\u7389\u9752 Yuh-Ching Twu \u806f\u7d61\u65b9\u5f0f \u53f0\u5317\u5e02\u5317\u6295\u5340\u77f3\u724c\u7acb\u8fb2\u8857\u4e8c\u6bb5155\u865f \u751f\u91ab\u5de5\u7a0b\u9928 205\u5ba4\u570b\u7acb\u967d\u660e […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-298","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/comments?post=298"}],"version-history":[{"count":64,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298\/revisions"}],"predecessor-version":[{"id":8217,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298\/revisions\/8217"}],"wp:attachment":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/media?parent=298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}