{"id":298,"date":"2021-03-25T01:48:03","date_gmt":"2021-03-25T01:48:03","guid":{"rendered":"http:\/\/dmt.nycu.edu.tw\/?page_id=298"},"modified":"2023-09-06T11:26:52","modified_gmt":"2023-09-06T03:26:52","slug":"%e6%b6%82%e7%8e%89%e9%9d%92","status":"publish","type":"page","link":"https:\/\/dmt.nycu.edu.tw\/en\/%e6%b6%82%e7%8e%89%e9%9d%92\/","title":{"rendered":"\u6d82\u7389\u9752"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"298\" class=\"elementor elementor-298\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7f685a8d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7f685a8d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-20410fa3\" data-id=\"20410fa3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3672c015 elementor-widget elementor-widget-heading\" data-id=\"3672c015\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.1 - 15-02-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">\u6d82\u7389\u9752\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-211d6aa8 elementor-widget elementor-widget-text-editor\" data-id=\"211d6aa8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.1 - 15-02-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Yuh-Ching Twu<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bb35b2f elementor-widget elementor-widget-image\" data-id=\"5bb35b2f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.1 - 15-02-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"628\" height=\"818\" src=\"https:\/\/dmt.nycu.edu.tw\/wp-content\/uploads\/2021\/09\/\u622a\u5716-2021-09-06-\u4e0b\u53481.54.10.png\" class=\"attachment-large size-large wp-image-2504\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/dmt.nycu.edu.tw\/wp-content\/uploads\/2021\/09\/\u622a\u5716-2021-09-06-\u4e0b\u53481.54.10.png 628w, https:\/\/dmt.nycu.edu.tw\/wp-content\/uploads\/2021\/09\/\u622a\u5716-2021-09-06-\u4e0b\u53481.54.10-230x300.png 230w\" sizes=\"(max-width: 628px) 100vw, 628px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-1d5487d1\" data-id=\"1d5487d1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e8e3cc2 elementor-widget elementor-widget-heading\" data-id=\"1e8e3cc2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u806f\u7d61\u65b9\u5f0f<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6774c93e elementor-widget elementor-widget-text-editor\" data-id=\"6774c93e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53f0\u5317\u5e02\u5317\u6295\u5340\u77f3\u724c\u7acb\u8fb2\u8857\u4e8c\u6bb5155\u865f \u751f\u91ab\u5de5\u7a0b\u9928 205\u5ba4<br \/>\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7cfb <br \/>\u96fb\u5b50\u90f5\u4ef6: yctwu@nycu.edu.tw<\/p><p>\u96fb\u8a71: 02-2826-7294 (Office)<br \/>02-2826-7000 ext. 65831 (Lab) <\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-646e76d8 elementor-widget elementor-widget-heading\" data-id=\"646e76d8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u5b78\u6b77<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f5432ec elementor-widget elementor-widget-text-editor\" data-id=\"3f5432ec\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 \u535a\u58eb\u00a0 (2003.9~2008.1)<\/p><p>\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7814\u7a76\u6240 \u78a9\u58eb (1997.9~1999.8)<\/p><p style=\"box-sizing: inherit; font-size: 15px; font-style: normal; font-weight: 400; user-select: auto; color: #3a3a3a;\">\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u6280\u8853\u5b78\u7cfb \u5b78\u58eb (1993.9~1997.6)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-607c912f elementor-widget elementor-widget-heading\" data-id=\"607c912f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u6388\u8ab2\u79d1\u76ee<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29540d0f elementor-widget elementor-widget-text-editor\" data-id=\"29540d0f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u8840\u5eab\u5b78\u3001\u8840\u6db2\u5b78\u8207\u81e8\u5e8a\u8840\u6db2\u5b78\u3001\u91a3\u8cea\u751f\u7269\u5b78\u3001\u8840\u6db2\u5b78\u53ca\u8840\u5eab\u5b78\u5be6\u9a57<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9215cd0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9215cd0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ab1ac87\" data-id=\"ab1ac87\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5d40ad83 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"5d40ad83\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.11.1 - 15-02-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#2c2c2c;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-adff60b elementor-widget elementor-widget-heading\" data-id=\"adff60b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\u5b78\u6b77<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25adb5f elementor-widget elementor-widget-text-editor\" data-id=\"25adb5f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 \u535a\u58eb (2003.9~2008.1)<br \/>\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u8853\u66a8\u6aa2\u9a57\u5b78\u7814\u7a76\u6240 \u78a9\u58eb (1997.9~1999.8)<br \/>\u967d\u660e\u5927\u5b78 \u91ab\u5b78\u6280\u8853\u5b78\u7cfb \u5b78\u58eb (1993.9~1997.6)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c6c903e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c6c903e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-69a8fc34\" data-id=\"69a8fc34\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-841a61d elementor-widget elementor-widget-heading\" data-id=\"841a61d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7d93\u6b77<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9eea9d1 elementor-widget elementor-widget-text-editor\" data-id=\"9eea9d1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u526f\u6559\u6388 \u967d\u660e\u4ea4\u901a\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u6aa2\u9a57\u5b78\u7cfb(2017.8~2023.7)<br \/>\u52a9\u7406\u6559\u6388 \u967d\u660e\u5927\u5b78 \u91ab\u5b78\u751f\u7269\u6280\u6aa2\u9a57\u5b78\u7cfb(2012.8~2017.7)<br \/>\u535a\u58eb\u5f8c\u7814\u7a76 Terry Fox Laboratory, BC Cancer Agency, Canada (2011.7~2012.7)<br \/>\u535a\u58eb\u5f8c\u7814\u7a76 Department of Microbiology and Immunology, University of British Columbia, Canada (2008.11~2011.6)<br \/>\u535a\u58eb\u5f8c\u7814\u7a76 \u53f0\u7063\u5927\u5b78 \u751f\u5316\u79d1\u5b78\u6240 (2008.2~2008.10) <\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4cd00e3c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4cd00e3c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3dfbdec8\" data-id=\"3dfbdec8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3b663d4f elementor-widget elementor-widget-heading\" data-id=\"3b663d4f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u65b9\u5411<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-742dabf elementor-widget elementor-widget-text-editor\" data-id=\"742dabf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: left;\">\u00a0 \u00a0 \u91a3\u5316\u4f5c\u7528 (glycosylation) \u70ba\u7d30\u80de\u4e2d\u91cd\u8981\u5f8c\u8f49\u8b6f\u4fee\u98fe\uff0c\u5176\u9664\u4e86\u53c3\u8207\u86cb\u767d\u8cea\u751f\u5408\u6210\u4e4b\u5916\uff0c\u8868\u73fe\u65bc\u7d30\u80de\u8868\u9762\u4e4b\u91a3\u5206\u5b50\u8207\u5176\u76f8\u5c0d\u61c9\u63a5\u53d7\u9ad4\u7d50\u5408\u5f8c\uff0c\u53ef\u6d3b\u5316\u4e0b\u6e38\u8a0a\u606f\u5206\u5b50\u4ee5\u8abf\u63a7\u5404\u9805\u751f\u7406\u529f\u80fd\u4ea6\u6216\u75c5\u7406\u8b8a\u5316\uff0c\u5982\u7d30\u80de\u589e\u751f\u3001\u5206\u5316\u3001\u764c\u5316\u4ee5\u53ca\u514d\u75ab\u76e3\u63a7\u4f5c\u7528\u3002\u7d30\u80de\u8868\u9762\u7570\u5e38\u91a3\u7d50\u69cb\u8b8a\u5316\u70ba\u816b\u7624\u7d30\u80de\u548c\u767d\u8840\u75c5\u7d30\u80de\u75c5\u7406\u8b8a\u5316\u7684\u91cd\u8981\u6a19\u8a8c\uff0c\u7a31\u70batumor-associated carbohydrate antigens (TACAs)\uff0c\u5982\u7570\u5e38\u9ad8\u5ea6\u553e\u6db2\u9178\u5316(hypersialylation) \u70ba\u6d88\u5316\u9053\u816b\u7624\u91cd\u8981\u7684\u6307\u6a19\u3002\u6b64\u8868\u73fe\u7570\u5e38\u553e\u6db2\u9178\u5316\u7684\u7d30\u80de\u53ef\u85c9\u7531\u8207\u514d\u75ab\u7d30\u80de\u8868\u9762\u76f8\u5c0d\u61c9\u91a3\u63a5\u53d7\u9ad4\u7d50\u5408\uff0c\u5982sialic acid-binding immunoglobulin-like lectins (Siglecs) \u7d50\u5408\uff0c\u4ee5\u9003\u812b\u514d\u75ab\u7d30\u80de\u4e4b\u76e3\u63a7\u4f5c\u7528\u3002\u6211\u7684\u7814\u7a76\u9818\u57df\u5305\u542b (1) \u7d30\u80de\u8868\u9762\u91a3\u4fee\u98fe\u8b8a\u5316\u5c0d\u81ea\u7136\u6bba\u624b\u7d30\u80de\u4e4b\u514d\u75ab\u76e3\u63a7\u529f\u80fd\u5f71\u97ff\uff1b\u548c (2) \u91a3\u63a5\u53d7\u9ad4sialic acid-binding immunoglobulin-like lectins-7 (Siglec-7) \u65bc\u514d\u75ab\u76e3\u63a7\u4f5c\u7528\u7684\u5f71\u97ff\u548c\u5176\u65bc megakaryopoiesis \u548c thrombopoiesis \u9020\u8840\u904e\u7a0b\u4e2d\u7684\u751f\u7406\u529f\u80fd\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3858e4f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3858e4f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-db100aa\" data-id=\"db100aa\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-04a80fc elementor-widget elementor-widget-heading\" data-id=\"04a80fc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7814\u7a76\u8457\u4f5c<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9af8e28 elementor-widget elementor-widget-text-editor\" data-id=\"9af8e28\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol><li>Huang YF, Su SC, Chuang HY, Chen HH, <strong><u>Twu YC<\/u><\/strong>*. 2023. Histone deacetylation-regulated cell surface Siglec-7 expression promoted megakaryocytic maturation and enhanced platelet-like particle release. Journal of Thrombosis and Haemostasis 21: 329-343<\/li><li>\u6797\u5abd\u5229(\u7e3d\u6821\u95b1),\u6731\u6b63\u4e2d,\u6731\u82b3\u696d,\u674e\u4fca\u5104,\u4f59\u69ae\u71be,\u4f55\u570b\u7dad,\u6797\u51a0\u5dde,\u6797\u60e0\u6dd1,\u6797\u5c0a\u6e44,\u6d2a\u82f1\u8056,\u5b6b\u5efa\u5cf0,<strong><u>\u6d82\u7389\u9752<\/u><\/strong>,\u5f35\u5c0f\u7433,\u5f35\u5fd7\u6607,\u5f35\u5efa\u570b,\u5f35\u9cf3\u5a1f,\u9673\u5b9a\u5e73,\u9673\u6dd1\u60e0,\u9673\u7005\u5982,\u7a0b\u4ec1\u5049, \u9ec3\u4ef0\u4ef0,\u694a\u5b5f\u6a3a,\u694a\u570b\u6881, \u842c\u7965\u9e9f,\u8449\u5ead\u5409,\u8a79\u8a60\u7d6e,\u5289\u5927\u667a, \u9ece\u857e,\u95d5\u5b97\u7199, \u7f85\u4ed5\u9321. 2023. \u8f38\u8840\u91ab\u5b78(\u7b2c\u516d\u7248)\u4e94\u5357\u51fa\u7248\u793e<\/li><li>Yeh YL, Tsao NT, <strong><u>Twu YC<\/u>*<\/strong>. 2023. Siglec-7 status modulates memory-like cytotoxicity in leukemia-primed human natural killer cells. J Biomed Lab Sci 35: 56-63<\/li><li>Lin WC, Lin CC, Lin YY, Yang WH, <strong><u>Twu YC<\/u><\/strong>, Teng HW, Hwang WL*. 2022. Molecular actions of exosomes and their theragnostic in colorectal cancer: current findings and limitation. Cellular Oncology 45: 1043-1052<\/li><li>Wu IW, Wu YL, Yang HY, Hsu CK, Chang LC, <strong><u>Twu YC<\/u><\/strong>, Chang YL, Chung WH, Yang CW, Hsieh WP, and Su SC*. 2022. Deep immune profiling of patients with renal impairment unveils distinct immunophenotypes associated with disease severity. <em>Clinical Kidney Journal<\/em><\/li><li>Wu YX, Lu HF, Lin YH, Chuang HY, Su SC*, Liao YJ*, <strong><u>Twu YC*<\/u><\/strong>. 2021. Branched I antigen regulated cell susceptibility against natural killer cell cytotoxicity through its N-linked glycosylation and overall expression. <em>Glycobiology<\/em> 31: 624-635<\/li><li>\u4f59\u69ae\u71be, \u738b\u660c\u73b2, \u6731\u6b63\u4e2d, \u6731\u5fd7\u82ac, \u6731\u82b3\u696d, \u4f55\u570b\u7dad, \u6797\u51a0\u5dde, \u6797\u5abd\u5229, <strong><u>\u6d82\u7389\u9752<\/u><\/strong>, \u5f35\u5c0f\u7433, \u5f35\u9cf3\u5a1f, \u9673\u5b9a\u5e73, \u9673\u5180\u5bec, \u9673\u7005\u5982, \u9678\u4e2d\u8861, \u9ec3\u4ef0\u4ef0, \u694a\u5b5f\u6a3a, \u842c\u7965\u9e9f, \u8a79\u8a60\u7d6e, \u8521\u6b23\u6021, \u9ece\u857e, \u7f85\u4ed5\u9321. 2021. \u8f38\u8840\u91ab\u5b78 (\u7b2c\u4e94\u7248) \u4e94\u5357\u51fa\u7248\u793e<\/li><li>Lee CY, Suk FM, <strong><u>Twu YC<\/u><\/strong> and Liao YJ*. 2020. Long-term exposure to low-dose Di-(2-ethylhexyl) phthalate impairs cholesterol metabolism in hepatic stella cells and exacerbates liver librosis. International Journal of Environmental Research and Public Health 17: 3802<\/li><li>Huang HT, Su SC, Chiou TJ, Lin YH, Shih YJ, Wu YX, Fan TH, and <strong><u>Twu TC<\/u><\/strong>*. DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5\u2019 promoter CpG sites. <em>Immunology<\/em> 160: 38-51<\/li><li>Wang YH, Suk FM, Liu CL, Chen TL, <strong><u>Twu YC<\/u><\/strong>*, Hsu MH*, Liao YJ*. 2020. Antifibrotic effects of a barbituric acid derivative on liver fibrosis by blocking the NF-KB signaling pathway in hepatic stellate cells. <em>Frontiers in Pharmacology<\/em> 11: 388<\/li><li>Wang YH, Liu CL, Chiu WC, <strong><u>Twu YC<\/u><\/strong>, Liao YJ*. 2019. HMGCS2 mediates ketone production and regulates the proliferation and metastasis of hepatocellular carcinoma. <em>Cancers<\/em> 11: 1876<\/li><li>Huang CH, Liao YJ, Chiou TJ, Huang HT, Lin YH, <strong><u>Twu YC<\/u><\/strong>*. 2019. TGF-b regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression. <em>Immunobiology<\/em> 224: 649-658<\/li><li>Wang YH, <strong><u>Twu YC<\/u><\/strong>, Wang CK, Lin FZ, Lee CY, and Liao YJ*. 2018. Niemann-Pick Type C2 protein regulates free cholesterol accumulation and influences hepatic stellate cell proliferation and mitochondrial respiration function. <em>International Journal of Molecular Sciences<\/em> 19<\/li><li>Yeh CC, Chang CJ, <strong><u>Twu YC<\/u><\/strong>, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, and Yu LC*. 2018. The molecular genetic background leading to formation of the human erythroid-specific Xg<sup>a<\/sup>\/CD99 blood groups. <em>Blood Advances<\/em> 2: 1854-1864<\/li><li>Huang CH, Liao YJ, Fan TH, Chiou TJ, Lin YH, <strong><u>Twu YC<\/u><\/strong>*. 2018. A developed NK-92MI cell line with Siglec-7neg phenotype exhibits high and sustainable cytotoxicity against leukemia cells. <em>International Journal of Molecular Sciences<\/em> 19<\/li><li>Yeh CC, Chang CJ, <strong><u>Twu YC<\/u><\/strong>, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, Yu LC* The differential expression of the blood group <em>P<sup>1<\/sup><\/em>&#8211;<em>A4GALT<\/em> and <em>P<sup>2<\/sup><\/em>&#8211;<em>A4GALT<\/em> alleles is stimulated by the transcription factor early growth response 1. <em>Transfusion<\/em> 58: 1054-1064<\/li><li>Lee YH, Liao YJ, Huang CH, Chang FL, Fan TH, and <strong><u>Twu YC<\/u><\/strong>*. Branched I antigens on leukemia cells enhanced sensitivity against NK cytotoxicity through affecting the target-effector interaction. <em>Transfusion <\/em>57: 1040-1051<\/li><li>Hsu MH, Hsu SM, Kuo YC, Liu CY, Hsieh CY, <strong><u>Twu YC<\/u><\/strong>, Wang CK, Wang YH, Liao YJ*. 2017. Treatment with low-dose sorafenib in combination with a novel benzimidazole derivative bearing a pyrolidine side chain provides synergistic anti-proliferative effects against human liver cancer. <em>RSC Advances<\/em> 7: 16253-16263<\/li><li>Liao YJ, Lee YH, Chang FL, Ho H, Huang CH, and <strong><u>Twu YC<\/u><\/strong>*. 2016. The SHP-2-ERK2 signaling pathway regulates branched I antigen formation by controlling the binding of C\/EBPa to the IGnTC promoter region during erythroid differentiation. <em>Transfusion<\/em> 56: 2691-2702<\/li><li>Liao YJ, Lee TS, <strong><u>Twu YC<\/u><\/strong>, Hsu SM, Yang CP, Wang CK, Liang YC and Chen YM*. 2016 Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes glconeogenesis by modulating the PI3K\/Akt pathway in the liver. Journal of Biomedical Science 23: 69-<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>,<\/strong> Lee TS, Lin YL, Hsu SM, Wang YH, Liao CY, Wang CK, Liang YC and Liao YJ*. 2016. Niemann-Pick type C2 protein mediates hepatic stellate cells activation by regulating free cholesterol accumulation. <em>International Journal of Molecular Science <\/em>17: 1-12<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>*<\/strong>, Teh HS. 2014. The ThPOK transcription factor differentially affects the development and function of self-specific CD8<sup>+<\/sup> T cells and regulatory CD4<sup>+<\/sup> T cells. <em>Immunology<\/em> 141:431-445<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Gold MR, Teh HS*. 2011. TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8(+) T cells. <em>European Journal of Immunology <\/em>41: 335- 344<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Hsieh CY, Lin M, Tzeng CH, Sun CF, Yu LC*. 2010. Phosphorylation status of transcription factor C\/EBPalpha determines cell-surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis. <em>Blood <\/em>115: 2491-2499<\/li><li>Wang HR, Hsieh CY, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Yu LC*. 2008. Expression of the human Sd(a) beta-1,4-N- acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status. <em>Glycobiology <\/em>18: 104-113<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chen CP, Hsieh CY, Tzeng CH, Sun CF, Wang SH, Chang MS, Yu LC*. 2007. I branching formation in erythroid differentiation is regulated by transcription factor C\/EBPalpha. <em>Blood <\/em>110: 4526-4534<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Hsieh CY, Yu LC*. 2006. Expression of the histo-blood group B gene predominates in AB- genotype cells. <em>Transfusion <\/em>46: 1988-1996<\/li><li>Lin M, Hou MJ, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Yu LC. 2005. A novel A allele with 664G&gt;A mutation identified in a family with the Am phenotype. <em>Transfusion <\/em>45: 63-69<\/li><li>Yu LC, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chou ML, Reid ME, Gray AR, Moulds JM, Chang CY, Lin M*. 2003. The molecular genetics of the human I locus and molecular background explain the partial association of the adult i phenotype with congenital cataracts. <em>Blood <\/em>101: 2081-2088<\/li><li><strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chou ML, Yu LC*. 2003. The molecular genetics of the mouse I beta-1,6-N- acetylglucosaminyltransferase locus. <em>Biochemical Biophysical Research Communications <\/em>303: 868-876<\/li><li>Sun CF, Yu LC, Chen IP, Chou DL, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Wang WT, Lin M*. 2003. Molecular genetic analysis for the Ae1 and A3 alleles. <em>Transfusion <\/em>43: 1138-1144<\/li><li>Yu LC, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chou ML, Chang CY, Wu CY, Lin M*. 2002. Molecular genetic analysis for the B(3) allele. <em>Blood <\/em>100: 1490-2<\/li><li>Yu LC, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chang CY, Lin M*. 2001. Molecular basis of the Kell-null phenotype: a mutation at the splice site of human KEL gene abolishes the expression of Kell blood group antigens. <em>Journal of Biological Chemistry <\/em>276: 10247-10252<\/li><li>Yu LC, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Chang CY, Lin M*. 2001. Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen. <em>Blood <\/em>98: 3840-3845<\/li><li>Yu LC, Chu CC, Chan YS, Chang CY, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Lee HL, Lin M*. 2001. Polymorphism and distribution of the Secretor alpha (1,2)-fucosyltransferase gene in various Taiwanese populations. <em>Transfusion <\/em>41: 1279-1284<\/li><li>Yu LC, Chang CY, <strong><u>Twu YC<\/u><\/strong><strong>, <\/strong>Lin M*. 2000. Human histo-blood group ABO glycosyltransferase genes: different enhancer structures with different transcriptional activities. <em>Biochemical Biophysical Research Communications <\/em>273: 459-466<\/li><li>Hsu HY*, <strong><u>Twu YC<\/u><\/strong><strong>. <\/strong> Tumor necrosis factor-alpha-mediated protein kinases in regulation of scavenger receptor and foam cell formation on macrophage. <em>Journal of Biological Chemistry <\/em>275: 41035-41048<\/li><\/ol><p><strong>\u00a0<\/strong><\/p><p><strong><u>\u00a0<\/u><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6d82\u7389\u9752 Yuh-Ching Twu \u806f\u7d61\u65b9\u5f0f \u53f0\u5317\u5e02\u5317\u6295\u5340\u77f3\u724c\u7acb\u8fb2\u8857\u4e8c\u6bb5155\u865f \u751f\u91ab\u5de5\u7a0b\u9928 205\u5ba4\u570b\u7acb\u967d\u660e &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/dmt.nycu.edu.tw\/en\/%e6%b6%82%e7%8e%89%e9%9d%92\/\"> <span class=\"screen-reader-text\">\u6d82\u7389\u9752<\/span> Read More &raquo;<\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":""},"_links":{"self":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298"}],"collection":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/comments?post=298"}],"version-history":[{"count":61,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298\/revisions"}],"predecessor-version":[{"id":5118,"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/298\/revisions\/5118"}],"wp:attachment":[{"href":"https:\/\/dmt.nycu.edu.tw\/en\/wp-json\/wp\/v2\/media?parent=298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}