[生技醫學講座] 05/06 國立中央大學 生命科學學系 羅月霞 副教授 講題:細胞自噬作用與腸道菌群失衡參與環境細懸浮微粒引起的結腸發炎

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5 year selected papers

  1. Tai-Jung Lu, Wei-Chung Chiou, Hsiu-Chen Huang, Heng-Chih Pan, Chiao-Yin Sun, Tzong-Der Way and Cheng Huang* (2024) Modulation of gut microbiota by crude gac aril polysaccharides ameliorates diet-induced obesity and metabolic disorders. International Journal of Biological Macromolecules. 13:133164. (IF=7.7, 6/95, 5.8%)
  2. Wei-Chung Chiou, Yi-Syuan Lyu, Tzu-Lan Hsia, Jui-Chieh Chen, Lie-Chwen Lin, Ming-Fu Chang, Meng-Shiuan Hsu, and Cheng Huang* (2024) Ergosterol peroxide blocks HDV infection as a novel entry inhibitor by targeting human NTCP receptor. Biomedicine & Pharmacotherapy. 170, 116077. (IF=6.9, 15/354, 4.1%)
  3. Wei-Chung Chiou, Guan-Jhong Huang, Tein-Yao Chang, Tzu-Lan Hsia, Hao-You Yu, Jir-Mehng Lo, Pin-Kuei Fu, and Cheng Huang* (2023) Ovatodiolide inhibits SARS-CoV-2 replication and ameliorates pulmonary fibrosis through suppression of the TGF-β/TβRs signaling pathway. Biomedicine & Pharmacotherapy. 161, 114481. (IF=6.9, 15/354, 4.1%)
  4. Wei-Chung Chiou, Wei-Han Lai, Yu-Lin Cai, Meng-Lun Du, Hsi-Mei Lai, Jui-Chieh Chen, Hsiu-Chen Huang, Hui-Kang Liu, and Cheng Huang* (2022) Gut microbiota-directed intervention with high-amylose maize ameliorates metabolic dysfunction in diet-induced obese mice. Food & Function. 13, 9481-9495. (IF=5.1, 33/173, 18.8%)
  5. Ting-Chen Chang, Wei-Chung Chiou, Wei-Han Lai, Hsiu-Chen Huang, Yu-Ling Huang, Hui-Kang Liu,Yu-Chih Liang, and Cheng Huang*. (2021) Ugonin J improves metabolic disorder and ameliorates nonalcoholic fatty liver disease by regulating the AMPK/AKT signaling pathway. Pharmacological Research. 163: 105298 (IF=9.1, 13/354, 3.5%)
  6. Hsing Huang, Hsiu-Chen Huang, Wei-Chung Chiou, Lie-Chwen Lin, Jui-Chieh Chen, Hui-Kang Liu, Yu-Heng Lai, and Cheng Huang*. (2021) Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP. Antiviral Research. 195: 105184 (IF=4.5, 60/354, 16.8%)
  7. Wei-Chung Chiou, Meng-Shiuan Hsu, Yun-Ti Chen, Jinn-Moon Yang, Yeou-Guang Tsay, Hsiu-Chen Huang, and Cheng Huang*. (2021) Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 147-153 (IF=5.6, 11/72, 14.6%)
  8. Wei-Chung Chiou, Bei-Hau Chang, Hsiao-Hsuan Tien, Yu-Lin Cai, Ya-Chi Fan, Wei-Jen Chen, Hui-Fang Chu, Yu-Hsin Chen and Cheng Huang*. (2021) Synbiotic intervention with an adlay-based prebiotic and probiotics improved diet-induced metabolic disturbance in mice by modulation of the gut microbiota. Nutrients. 13: 3161 (IF=4.8, 18/114, 15.4%)
  9. Wei-Chung Chiou, Hsu-Feng Lu, Nung-Yu Hsu, Tein-Yao Chang, Yuan-Fan Chin, Ping-Cheng Liu, Jir-Mehng Lo, Yeh B Wu, Jinn-Moon Yang and Cheng Huang*. (2021) Ugonin J acts as a SARS-CoV-2 3C-like protease inhibitor and exhibits anti-inflammatory properties. Frontiers in Pharmacology. 12: 720018 (IF=4.4, 65/354, 18.2%)
  10. Hsiu-Chen Huang, Chiung-Ju Chen, Yu-Heng Lai, Yu-Chun Lin, Wei-Chung Chiou, Hsu-Feng Lu, Ying-Fang Chen, Yu-Hsin Chen, and Cheng Huang*. (2021) Momordica cochinchinensis Aril Ameliorates Diet-induced Metabolic Dysfunction and Nonalcoholic Fatty Liver by Modulating Gut Microbiota. International Journal of Molecular Sciences. 22(5): 2640-2650 (IF=4.9, 66/313, 20.9%)
  11. Hao Chiang, Jinq-Chyi Lee, Hsiu-Chen Huang, Hsing Huang, Hui-Kang Liu, and Cheng Huang*. (2020) Delayed intervention with a novel SGLT2 inhibitor NGI001 suppresses diet-induced metabolic dysfunction and nonalcoholic fatty liver disease in mice. British Journal of Pharmacology. 177: 239-253. (IF=6.8, 18/354, 4.9%)
  12. Hsu-Feng Lu, Yu-Heng Lai, Hsiu-Chen Huang, I-Jung Lee, Lie-Chwen Lin, Hui-Kang Liu, Hsiao-Hsuan Tien, and Cheng Huang*. (2020) Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis and insulin resistance in mice. Journal of Ginseng Research. 44: 238-246 (IF=6.8, 1/43, 1.2%)
  13. Wei-Chung Chiou, Jui-Chieh Chen, Yun-Ti Chen, Jinn-Moon Yang, Lih-Hwa Hwang, Yi-Shuan Lyu, Hsin-Yi Yang, Cheng Huang*. (2020) The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease. Biochemical and Biophysical Research Communications. 591: 130-136 【A highly cited paper from Web of Science (WOS)】 (IF=2.5, 43/77, 55.2%)
  14. Cheng Huang, Yu-Ling Huang, Chia-Chi Wang, Yi-Ling Pan, Yu-Heng Lai, and Hsiu-Chen Huang. (2019) Ampelopsin A and ampelopsin C induce apoptosis and metastasis through down-regulating AxL, TYRO3, and FYN expressions in MDA-MB-231 breast cancer cells. Journal of Agricultural and Food Chemistry. 67(10):2818-2830 (IF=5.7, 7/89, 7.3%)
  15. Hsiu-Chen Huang, Hsu-Feng Lu, Yu-Heng Lai, Chung-Pei Lee, Hui-Kang Liu, and Cheng Huang*. (2019) Tat-enhanced delivery of the C terminus of HDAg-L inhibits assembly and secretion of hepatitis D virus. Antiviral Research. 150:69-78 (IF=4.5, 60/354, 16.8%)

 

Other papers

  1. Ming-Shan Chen, Zhi-Yong Chong, Cheng Huang, Hsiu-Chen Huang, Pin-Hsuan Su, Jui-Chieh Chen. (2024) Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells. Oncology Reports. 51(5):72.
  2. Cheng Huang, Zi-Jun Lin, Jui-Chieh Chen, Hao-Jun Zheng, Yu-Heng Lai, Hsiu-Chen Huang (2023) α-viniferin induced apoptosis through downregulation of SIRT1 in non-small cell lung cancer NCI-H460 cells in vitro and in  Pharmaceuticals. 16: 727 (First author) (IF=4.6; PHARMACOLOGY & PHARMACY, 72/277, 25.8%)
  3. Jen-Tsung Yang, I-Neng Lee, Cheng Huang, Hsiu-Chen Huang, Yu-Ping Wu, Zhi-Yong Chong, Jui-Chieh Chen (2023) ADAM17 confers temozolomide resistance in human glioblastoma cells and miR-145 regulates its expression. International Journal of Molecular Sciences. 24(9):7703
  4. Jui-Chieh Chen, Hsun-Chang Shih, Chih-Yang Lin, Jeng-Hung Guo, Cheng Huang, Hsiu-Chen Huang, Zhi-Yong Chong, Chih-Hsin Tang (2023) MicroRNA-631 resensitizes doxorubicin-resistant chondrosarcoma cells by targeting apelin. International Journal of Molecular Sciences. 24: 839
  5. Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien, and Cheng Huang* (2022) Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus. Virology Journal. 19(1):163. 【*Corresponding author】 (IF=4.8; VIROLOGY, 14/36, 37.5%)
  6. Wei-Chung Chiou, Cheng Huang*, Zi–Jun Lin, Lian-Sheng Hong, Yu-Heng Lai, Jui-Chieh Chen, and Hsiu-Chen Huang. (2022) ε-Viniferin and α-viniferin inhibited TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in lung cancer cells through downregulation of vimentin expression. Nutrients. 14, 2294. (*Equal contribution) (IF=5.9; NUTRITION & DIETETICS, 17/88, 18.7%)
  7. Ashish Rao Sathyanarayana, Chung-Kuang Lu, Chih-Chuang Liaw, Chia-Chuan Chang, Hsin-Ying Han, Brian D. Green, Wei-Jan Huang, Cheng Huang, Wen-Di He, Lin-Chien Lee, and Hui-Kang Liu. (2022) 1,2,3,4,6-Penta-O-galloyl-D-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice with Diet-Induced Obesity. International Journal of Molecular Sciences. 23: 4052
  8. Cheng Huang*, Zi Jun Lin, Cheng-Ju Lee, Wei-Han Lai, Jui-Chieh Chen, and Hsiu-Chen Huang. (2021) e-Viniferin and a-viniferin alone or in combination induced apoptosis in osteosarcoma and non-small cell lung cancer cells. Food and Chemical Toxicology. 158: 112617 (First author) (IF=4.3; TOXICOLOGY, 20/94, 20.7%)
  9. Semon Wu, Cheng Huang, You-Ren Chen, Hsiu-Chen Huang, Wen-Cheng Huang, Yu-Heng Lai. (2021) Momordica charantia leaf extract reduces hepatic lipid accumulation and diet-induced dyslipidemia in zebrafish through lipogenesis and beta-oxidation. Journal of Functional Foods. 87: 104857.
  10. I-Neng Lee, Jen-Tsung Yang, Cheng Huang, Hsiu-Chen Huang, Yu-Ping Wu, and Jui-Chieh Chen. (2021) Elevated XRCC5 expression can promote temozolomide resistance and predict poor prognosis in glioblastoma. Oncology Letters. 21(6):443.
  11. Yu-Chun Lin, Hsu-Feng Lu, Jui-Chieh Chen, Hsiu-Chen Huang, Yu-Hsin Chen, Yen-Shuo Su, Chien-Yi Tung, Cheng Huang*. (2020) Purple-leaf Tea (Camellia sinensis) Ameliorates High-fat Diet Induced Obesity and Metabolic Disorder through the Modulation of the Gut Microbiota in Mice. BMC Complementary Medicine and Therapies. 20: 376-387 (* Corresponding author) (IF=3.9; INTEGRATIVE & COMPLEMENTARY MEDICINE, 9/28, 30.4%)
  12. Hao Chiang, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Hsin Chen, Hsi-Tai Sun, Hsiu-Chen Huang, Hsiao-Hsuan Tien, and Cheng Huang*. (2020) Adlay Seed (Coix lacryma-jobi) Extracts Exhibit a Prophylactic Effect on Diet-Induced Metabolic Dysfunction and Nonalcoholic Fatty Liver Disease in Mice. Evidence-Based Complementary and Alternative Medicine. 2020:9519625. doi: 10.1155/2020/9519625. (* Corresponding author) (IF=2.650; INTEGRATIVE & COMPLEMENTARY MEDICINE, 16/30, 53.3%)
  13. Ting-Chen Chang, Hao Chiang, Yu-Heng Lai, Yu-Ling Huang, Hsiu-Chen Huang, Yu-Chih Liang, Hui-Kang Liu, and Cheng Huang*. (2019) Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. BMC Complementary Medicine and Therapies. 19: 368-378 (* Corresponding author) (IF=3.9; INTEGRATIVE & COMPLEMENTARY MEDICINE, 9/28, 30.4%)
  14. Cheng Huang, Hsu-Feng Lu, Yu-Hsuan Chen, Jui-Chieh Chen, Wen-Hsiang Chou, Hsiu-Chen Huang. (2020) Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and –independent apoptosis via Smad or Akt signaling pathways in HOS cells. BMC Complementary Medicine and Therapies. 20:68-78 (First author) (IF=3.9; INTEGRATIVE & COMPLEMENTARY MEDICINE, 9/28, 30.4%)
  15. Ming-Ju Hsieh, Cheng Huang*, Chia-Chieh Lin, Chih-Hsin Tang, Chih-Yang Lin, I-Neng Lee, Hsiu-Chen Huang, and Jui-Chieh Chen. (2019) Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression. Molecular Carcinogenesis. 59: 293-303 (*Equal contribution) (IF=4.6; BIOCHEMISTRY & MOLECULAR BIOLOGY, 97/285, 34.8%)
  16. Ming‑Ju Hsieh, Yin‑Hong Chen, I‑Neng Lee, Cheng Huang, Yu‑Ju Ku and Jui‑Chieh Chen. (2019) Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma. International Journal of Oncology. 55: 949-959
  17. Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin, Jen-Tsung Yang. (2019) Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells. BMC Cancer. 19(1):756-760
  18. Lie-Chwen Lin, Lin-Chien Lee, Cheng Huang, Chiung-Tong Chen, Jen-Shin Song, Young-Ji Shiao, Hui-Kang Liu. (2019) Effects of Boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1. 62: 152946-152956
  19. Yen-Chang Lin, Cheng Huang*, Hsiu-Chen Huang, Ming-Ting Liao, Yu-HengLai. (2019) Metabolomics profiling of haloperidol and validation of thromboxane-related signaling in the early development of Biochemical and Biophysical Research Communications. 513(3):608-615 (*Equal contribution) (IF=3.1; BIOPHYSICS, 33/70, 46.4%)
  20. Yu-Chun Lin, Cheng Huang, Hsin-Chih Lai. (2019) Revealing the ultrastructure of the membrane pores of intact Serratia marcescens cells by atomic force microscopy. Heliyon. 5:e02636
  21. Jui-Chieh Chen, Cheng Huang, I-Neng Lee, Yu-Ping Wu, Chih-Hsin Tang. (2018) Amphiregulin enhances cell migration and resistance to doxorubicin in chondrosarcoma cells through the MAPK pathway. Molecular Carcinogenesis. 57(12):1816-1824
  22. Han-Min Chen, Lin-Chien Lee, Kuang-Yu Hu, Wei-Jern Tsai, Cheng Huang, Hui-Jen Tsay, Hui-Kang Liu. (2018) The Application of Post-Translational Modification Oriented Serum Proteomics to Assess Experimental Diabetes with Complications. PLOS ONE. 13(11):e0206509
  23. Yu-Heng Lai, Cheng-Pu Sun, Hsiu-Chen Huang, Jui-Chieh Chen, Hui-Kang Liu and Cheng Huang*. (2018) Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric. BMC Complementary Medicine and Therapies. 18:248-254 (* Corresponding author) (IF=3.9; INTEGRATIVE & COMPLEMENTARY MEDICINE, 9/28, 30.4%)
  24. Liu GT, Kung HN, Chen CK, Huang C, Wang YL, Yu CP, Lee CP. (2018) Improving nuclear envelope dynamics by EBV BFRF1 facilitates intranuclear component clearance through autophagy. FASEB Journal. 32(7):3968-3983
  25. Huang HC, Lee CP, Liu HK, Chang MF, Lai YH, Lee YC, Huang C*. (2016) Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus. Journal of Biological Chemistry. 291(50):26226-26238. 【*Corresponding author】 (IF=4.8; BIOCHEMISTRY & MOLECULAR BIOLOGY, 88/285, 30.7%)
  26. Huang C, Wei YX, Shen MC, Tu YH, Wang CC, Huang HC. (2016) Chrysin, Abundant in Morinda citrifolia Fruit Water-EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells. Journal of Agricultural and Food Chemistry. 64:4235-45 (First author) (IF=6.1; AGRICULTURE, MULTIDISCIPLINARY, 6/58, 9.5%)
  27. Tseng TS, Chuang SM, Hsiao NW, Chen YW, Lee YC, Lin CC, Huang C, Tsai KC. (2016) Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations. Molecular Biosystems. 12(8):2541-51. doi: 10.1039/c6mb00229c.
  28. Cheng Huang, Chung-Kuang Lu, Ming-Chin Tu, Jia-Hua Chang, Yen-Ju Chen, Yu-Hsuan Tu, and Hsiu Chen Huang. (2016) Polyphenol-rich Avicennia marina leaf extracts induce apoptosis in human breast and liver cancer cells and in a nude mouse xenograft model. Oncotarget. 7(24):35874-35893. doi: 10.18632/oncotarget.8624. (First author)
  29. Hui-Kang Liu, Tzu-Min Hung, Hsiu-Chen Huang, I-Jung Lee, Chia-Chuan Chang, Jing-Jy Cheng, Lie-Chwen Lin, and Cheng Huang*. (2015) Bai-Hu-Jia-Ren-Shen-Tang Decoction Reduces Fatty Liver by Activating AMP-activated Protein Kinase In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2015/651734 (* Corresponding author) (IF=2.650; INTEGRATIVE & COMPLEMENTARY MEDICINE, 16/30, 53.3%)
  30. Cheng Huang, Yi-Jing Chen, Wei-Jen Chen, Chih-Li Lin, Yu-Xuan Wei, and Hsiu-Chen Huang. (2015) Combined treatment with chrysin and 1,2,3,4,6-penta-O-galloyl-β-D-glucose synergistically inhibits LRP6 and Skp2 activation in triple-negative breast cancer and xenografts. Molecular carcinogenesis. 54:1613-25 (First author) (IF=4.6; BIOCHEMISTRY & MOLECULAR BIOLOGY, 97/285, 33.9%)
  31. Hsiu-Chen Huang, Mi-Hua Tao, Tzu-Min Hung, Jui-Chieh Chen, Zi-Jun Lin, Cheng Huang*. （2014）(-)-Epigallocatechin-3-gallate Inhibits Entry of Hepatitis B Virus into Hepatocytes. Antiviral Research. 111:100-111 (* Corresponding author) (IF=7.6; PHARMACOLOGY & PHARMACY, 20/277, 0%)
  32. Sheng-Fan Wang, Yueh-Ching Chou, Nirmal Mazumder, Fu-Jen Kao, Leslie D. Nagy, F. Peter Guengerich, Cheng Huang, Hsin-Chen Lee, Ping-Shan Lai, Yune-Fang Ueng. (2013) 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochemical Pharmacology 86(4):548-60.
  33. Huang C, Lee SY, Lin CL, Tu TH, Chen LH, Chen YJ, and Huang HC. (2013) Co-treatment with Quercetin and 1,2,3,4,6-Penta-O-galloyl-β-d-glucose Causes Cell Cycle Arrest and Apoptosis in Human Breast Cancer MDA-MB-231 and AU565 Cells. Journal of Agricultural and Food Chemistry 61: 6430−6445 (First author) (IF=6.1; AGRICULTURE, MULTIDISCIPLINARY, 6/58, 9.5%)
  34. Cheng Huang, Jia-Yin Jiang, Shin C. Chang, Yeou-Guang Tsay, Mei-Ru Chen, and Ming-Fu Chang. (2013) NESI Protein Forms Complexes with Lamin A/C-Nups to Mediate the CRM1-Independent Nuclear Export of Large Hepatitis Delta Antigen. Journal of Virology. 87:1596-604 (First author) (IF=5.4; VIROLOGY, 11/36, 29.2%)
  35. Pei-Yun Chuang, Cheng Huang, and Hsiu-Chen Huang. (2013) The use of a combination of tamoxifen and doxorubicin synergistically to induce cell cycle arrest in BT483 cells by down-regulating CDK1, CDK2 and cyclin D expression. Journal of Pharmaceutical Technology & Drug Research 2: 1-4
  36. Hsiu-Chen Huang, 6-Chi Chen, Wen-Cheng Chang, Mi-Hua Tao, and Cheng Huang*. (2012) Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis. Journal of Virology. 86:9443-9453 (* Corresponding author) (IF=5.4; VIROLOGY, 11/36, 29.2%)
  37. Shih-Han Sun, Hsiu-Chen Huang, Cheng Huang, Jen-Kun Lin. (2012) Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. European Journal of Pharmacology. 690:22-30
  38. Cheng Huang, Shin C. Chang, Hui-Chin Yang, Chung-Liang Chien, and Ming-Fu Chang (2009) Clathrin-mediated post-Golgi trafficking in the morphogenesis of hepatitis delta virus. Journal of Virology. 83:12314-12324 (First author) (IF=5.4; VIROLOGY, 11/36, 29.2%)
  39. Tzu-Min Hung, Shin C. Chang, Wei-Hsuan Yu, Yu-Wen Wang, Cheng Huang, Shao-Chun Lu, Po-Huang Lee, and Ming-Fu Chang (2009) A novel nonsynonymous variant of matrix metalloproteinase-7 confers risk of liver cirrhosis. 50:1184-1193
  40. Cheng Huang, Shin C. Chang, I-Chen Yu, Yeou-Guang Tsay, and Ming-Fu Chang (2007) Large hepatitis delta antigen is a novel clathrin adaptor-like protein. Journal of Virology. 81:5985-5994. A highlight from journal selection. (First author) (IF=5.4; VIROLOGY, 11/36, 29.2%)
  41. Yun-Hsin Wang, Shin C. Chang, Cheng Huang, Ya-Ping Li, Chia-Huei Lee, and Ming-Fu Chang. (2005) Novel nuclear export signal interacting protein, NESI, critical for the assembly of hepatitis delta virus. Journal of Virology. 79:8113-8120